Jul 032012
 

Where we’ve come from, where we are, and where we’re going

Travel with Dave from the beginning – and before the beginning – of GCP, and how the Programme will be brought to an orderly close. Dave also elaborates on the role of the Consortium Committee.

There’s no doubt that the Programme has enabled new partnerships and rekindled and rejuvenated old or existing partnerships amongst the different partners. Some of these are between the different CGIAR Centres and others are between these Centres and partners outside the CGIAR. These partnerships have been very fruitful.

People speak of GCP almost as if it were the 16th Centre. They speak of it with pride and respect. They understand the important role it can play.

GCP has a lot of credibility with national programmes. When you go to GCP’s General Research Meetings, there’s clearly a feeling of being part of the community, and that we are all improving our efficiency because of the Programme.

…I think it’s been one of the more successful Challenge Programmes.

Dave Hoisington (pictured)  is the Chair of GCP’s Consortium Committee, and currently ICRISAT’s Director of Research. Dave was previously with CIMMYT, GCP’s host Centre. He has therefore been involved with GCP “since day minus one” in his words. “It’s equally exciting to be involved in the Programme’s closure, because I think that is even more important with regard to keeping its legacy alive.” Dave now walks us through the workings of the Programme today, its achievements and challenges, and what the early formative years were like….

What is the role of the GCP Consortium Committee?
GCP was set up as a multi-institutional endeavour. As an elaborate and broad partnership representing various interests, the decision at the Programme’s inception was to set up a committee representing all the key members from CGIAR Centres, developing-country programmes and advanced research institutes.

This Consortium Committee is ultimately the one that ‘owns’ GCP and oversees the basic functioning of the Programme to make sure that it is going in the right direction. We have an Executive Board which the Consortium appointed and it’s that Executive Board that Jean-Marcel [GCP Director] reports to. Because we set up the Board, they actually report to us.

…by having this Committee of the key players in research as well as an independent Board, we can all make sure GCP is going in the right direction, by giving voice to both the ‘players’ and ‘referees’.

Why have a Committee as well as a Board, and why seek broad partnerships?
During a mid-term review of GCP, the need for both a Committee and an independent Executive Board was recognised to give the Programme more structure and guidance. The Consortium Committee was established in 2008, and its precursor was the Programme Steering Committee.

GCP is not a research programme run by a single institute but really a consortium to enhance effectiveness. So, by having this Committee of the key players in research as well as an independent Board, we can all make sure GCP is going in the right direction, by giving voice to both the ‘players’ and ‘referees’.

There’s no doubt that the Programme has enabled new partnerships and rekindled and rejuvenated old or existing partnerships amongst the different partners. Some of these are between the different CGIAR Centres and others are between these Centres and partners outside the CGIAR. These partnerships have been very fruitful.

GCP’s tagline – ‘Partnerships in modern crop breeding for food security’ – what does this mean for you?
It really captures the essence of GCP – GCP is about creating opportunities for these partnerships. It’s about using a modern approach, a more integrated approach to breeding, to aid food security in the developing world.

Why is GCP’s work important?
The whole premise of setting up GCP 10 years ago was really the fact that our major crops were not registering the necessary increases in yield to meet food needs in developing countries. There are many reasons for that. The reason that became the main driving force for GCP was that we had not been able to tap the rich genetic diversity that exists for almost all of these crops. So the idea was to come up with mechanisms, methods, examples and proofs-of-concept that tap into this genetic diversity, and package it such that breeding programmes can integrate it into their operations. By so doing, we would broaden the horizon of breeding programmes for more rapid gains in yields and productivity in farmers’ fields.

Originally, the whole idea was mostly a proof-of-concept. Once we realised it could work, we realised that capacity needed to be built within national programmes since GCP’s scope was 10 years. So, the emphasis began to rightly shift from exploration and discovery to application and impact, buttressed by more training and capacity building within national programmes for sustainability. Genetic research was – and still remains – the backbone, but there has been a growing reliance on other tools including IT and molecular breeding. Now the technology has matured, costs have decreased, making it more viable for public research.

Unfortunately, we don’t have the alternative case of what it would have been like without GCP… but I think that many institutes within and outside CGIAR are trying to use genomics as a technology, and I think a lot of that can be traced back to projects that GCP supported.

What have been the major outcomes of GCP so far?
The greatest overall outcome is a stronger awareness and use of genomics in our research programmes across the board.

Unfortunately, we don’t have the alternative case of what it would have been like without GCP, which we could compare to, but I think that many institutes within and outside CGIAR are trying to use genomics as a technology, and I think a lot of that can be traced back to projects that GCP supported and encouraged.

In the early years, characterisation of genetic resources was very beneficial and it’s encouraging to see it still continues, with characterising genetic resources now considered routine.

What outcomes are you most looking forward to?
I think one of the most promising, and potentially important outcomes will be the adoption of GCP’s Integrating Breeding Platform.

‘Challenge’ is in GCP’s name. What are the major challenges that the Programme has so far overcome?
When GCP was being designed, there was no definition or case study for what a Challenge Programme had to do. The preliminary idea was that for projects to succeed and overcome major challenges, partnerships were key and no single institute could do it alone: they needed to do business differently, whether among the CGIAR Centres, or with partners outside the CGIAR. We had all these genebanks, all this diversity, genetic and genomic tools for some crops but not all crops. So, we put our heads together and asked ourselves, “What if we combine these modern molecular approaches used in one crop and apply them to another crop? Can we unlock the genetic diversity within it to improve quality and yield? How do we get all partners to work together towards a common goal?”

At the beginning, GCP had probably way too many facets and we were trying to move ahead on all the different fronts, so I think the mid-term reshaping and redefinition of the Programme helped it gain more focus to actually do what it set out to do.

GCP has built capacity, tools, methodologies and technologies. All these need to continue so as to increase and improve outputs and enhance outcomes.

What future challenges must the Programme overcome to remain sustainable?
Ensuring its achievements are sustained. While it was a time-bound programme from day one, the results and successes are not time-bound. They should be sustained and continued in other shapes and forms.

The challenge now is filtering these successes and figuring out how best to continue them. GCP has built capacity, tools, methodologies and technologies. All these need to continue so as to increase and improve outputs and enhance outcomes.

What are the main lessons learnt so far?
Partnerships are not easy. They take a lot of time. It’s one thing to write a proposal and say we will work together but it’s another thing to make that work effectively. I know GCP has had some instances where partners brought in have not been effective. I’m sure the GCP management has learnt lessons on how to deal with that.

People work together because they trust and respect one another and recognise and understand each other’s roles. They don’t view it as a competition. Some partnerships occur spontaneously, while others take time. They have to build trust, understanding and communication.

We’ve all learnt lessons from the research side, such as what does and doesn’t work. Focussing was a good lesson that GCP and all of us have learnt. At the beginning, we just spread ourselves too thin, trying to do too many things, making it very difficult to measure progress.

What is the most enjoyable aspect of your involvement with GCP?
I’ve been involved in GCP from day minus one. I used to be at CIMMYT and was involved in the ‘pre-pre-birth’ of the Programme, even before it had been conceptualised. Through the years since then, I’ve had different levels of engagement – and even periods of disengagement – but have always enjoyed my involvement.

It’s always been a good group of people working together, even when there have been problems. I think the Programme has scored high on successes. Jean-Marcel and his team deserve a lot of credit. They’ve really been able to keep the momentum going.

It’s equally exciting to be involved in the Programme’s closure, because I think that is even more important with regard to keeping its legacy alive.

People speak of GCP almost as if it were the 16th Centre. They speak of it with pride and respect. They understand the important role it can play.

GCP has a lot of credibility with national programmes… Ithink it’s been one of the more successful Challenge Programmes.

Jean-Marcel talks of the ‘GCP spirit’ and how successful partners share this spirit. What are your thoughts on this?
GCP definitely has a strong ‘entity’, although I’m not sure if this is a spirit! People speak of GCP almost as if it were the 16th Centre. They speak of it with pride and respect. They understand the important role it can play.

GCP has a lot of credibility with national programmes. When you go to GCP’s General Research Meetings, there’s clearly a feeling of being part of the community, and that we are all improving our efficiency because of the Programme.

I think it’s been one of the more successful Challenge Programmes.

Relevant links

 

Jul 012012
 

A shared vision

What is GCP all about and why is its work important? Why was GCP created? Read recollections from key people involved in GCP’s conceptualisation, and find out how realisation of the shared vision continues today. Featuring candid conversations with Masa Iwanaga, former Director General, CIMMYT; Dave Hoisington, Consortium Committee Chair; Andrew Bennett, Executive Board member; and Jean-Marcel Ribaut, GCP Director.

When was the last time you went to your local shop to buy something only to be told they’ve run out of it? How did you react? Like most of us, did you question how they could have run out – after all, isn’t it their business to adequately supply the demand?

Most likely you just went to another store. But what if there wasn’t another store around that had your product, or worse, there was actually a national shortage of your product? This is the reality that faces not just those after the latest iPad, but billions of people who just want something, anything, to eat.

With less productive land on which to grow crops, a more variable climate and more extreme weather events, farmers across all continents are struggling to produce crops, let alone increase yields to meet an ever-growing demand.

This scenario has continually raised its ugly head over the last 200 years as the world’s population has grown exponentially and shifted to urban surroundings. If not for the Green Revolution, inspired by the late Norman Borlaug’s agricultural development research within the Office of Special Studies in Mexico (now the International Maize and Wheat Improvement Center, more commonly known as CIMMYT, its Spanish acronym), the world population would have already suffered losses into the billions.

Even so, food insecurity is still recognised as a global challenge by the UN’s Food and Agriculture Organization (FAO). While there is debate over the cause for such insecurity, the advances of agricultural technology born from a Mexican-flavoured research programme are once again coming to the fore to meet the challenge.

Genebanks are not limited to conservation but are also a source of new alleles for crop improvement.

The genies in the genebank
Seedbank collections serve as insurance against unanticipated future threats to food security, the degradation of our environment and the loss of plant biodiversity.

But that is not all: the banks are not limited to conservation but are also a source of new alleles for crop improvement. The temperature-controlled CGIAR genebanks are a veritable treasure trove for plant breeding. Over the past four decades, their curators have scoured the planet, collecting, categorising and conserving more than 650,000 samples of crop, forage and agroforestry genetic resources, held in trust on behalf of humanity.

One such temperature-controlled genebank is located just outside the sweltering Mexico City: the CIMMYT genebank holds more than 150,000 unique samples of wheat and its relatives from more than 100 countries – said to be the largest collection of a single crop.

While genebank ‘stocks’ have always been open to plant breeders, it wasn’t until 2002 that CGIAR researchers embarked on a more structured and systematic approach using modern technologies to tap their breeding potential, thereby elevating the genebanks beyond their traditional collection and conservation role. Prior to that, far-sighted individual pioneering researchers had been studying (termed ‘screening’ in breeder-speak) the stocks for solutions to breeding problems and to improve crops, but the turning point for a concerted ‘institutional’ effort, would come in the early noughties.

By studying the genes of wild versions of, let’s say, wheat, researchers can find genes that could help cultivated wheat to better battle drought.

The dawn of a new generation
One of these researchers was Dave Hoisington (pictured), then with CIMMYT, and now Chair of GCP’s Consortium Committee, and ICRISAT’s Director of Research. Dave worked with the then newly appointed CIMMYT Director General, Masa Iwanaga, and helped draft a joint proposal with other institutes to CGIAR to form a Challenge Programme that could use the recent advances in molecular biology to harness their rich global stocks of crop genetic resources to create and provide a new generation of plants to meet farmers’ needs. This successfully gave rise to the CGIAR Generation Challenge Programme.

“GCP’s first task was to go in and identify the genetic wealth held within the CGIAR banks,” says Dave.

“To do this, we wanted to use the most recent molecular tools, like molecular markers, to help scan the genomes and discover genes in species related to crops of interest that could help increase yield.”

Let’s use an analogy from a familiar medium – text: think of this story you are now reading as the plant’s genome, its words as its genes and a molecular marker as a text highlighter. You can use different markers to highlight different keywords in this story. Once you can see these keywords, you can then study them in more detail, and, in the case of genes, see what they control in the plant, and how they affect its different aspects.

Photo: JIRCASBy studying the genes of wild versions of, let’s say, wheat, researchers can find genes that could help cultivated wheat to better battle drought.

“At that time, we recognised that a Centre like CIMMYT could no longer undertake this tremendously complex task on its own,” recounts Masa (pictured).”We needed to work within a programme that could concentrate on the task and that rallied together various CGIAR Centres as well as research institutes outside CGIAR, especially in developing countries.”

Partnerships with spirit
Partnerships have always been a key ingredient to success. At the same time, they have led to the downfall of many projects.

Back in the early noughties, CGIAR recognised their business model and research system were not actively fostering partnerships between their different research Centres as much as they should have been, nor were they vigorously encouraging Centres to seek collaboration outside CGIAR.

This was one of the fundamental reasons for establishing the Challenge Programmes, says Jean-Marcel Ribaut (pictured), who, in his role as GCP Director, has been credited by the Board and Committee for the significant time he has taken to broker, nurture and manage GCP’s partnerships.

“One of our major outputs has been the human assets,” says Jean-Marcel with great pride. “We have created this amazing chain of people from the lab to the field.”

In fact, GCPs greatest asset – its ‘crown jewel’ – is its network of people and the capacity the Programme provides them with to buttress all the hard work, particularly in countries where the end products (crops) will be of most benefit.

…the GCP Spirit’ … is visible and palpable: you can recognise people working with us have a spirit that is typical of the Programme.”

“To make a difference in rural development, to truly contribute to improved food security through crop improvement and income for poor farmers, we knew we had to build capacity in these areas,” observes Jean-Marcel.

“I see our management style as fairly ‘paternal’, in the positive sense of wanting to see these groups of people succeed, and us helping them to do so. If a research site needs a pump for fieldwork, we work with a local or international consultant who will visit the partner and evaluate their needs, advise them on what type of pump they need, as well as other infrastructure they’ll need for the whole system to be sustainable. We’ll then provide training on how to use the pump most effectively. It’s an investment in the people as much as in the products they are working on because we are trying to change the system of how science within partnerships is conducted and supported, as much as we are trying tap genetic diversity and breed resilient crops for the developing world.”

We were attracted to GCP because of its strong facilitating role, which offered considerable support to addressing the bottlenecks associated with research programmes that researchers and CGIAR identified.”

This support and change have been major selling points for potential partners who have resonated with what Jean-Marcel calls ‘the GCP Spirit’ – partners open to sharing their skills, tools and knowledge, willing to sacrifice their views and leadership and, most importantly, support one another.

“It is visible and palpable: you can recognise people working with us have a spirit that is typical of the Programme,” says Jean-Marcel.

Funders like the Swiss Agency for Development and Cooperation (SDC) are attracted to, and impressed by, GCP’s approach as an honest and impartial ‘broker’.

“We were attracted to GCP because of its strong facilitating role, which offered considerable support to addressing the bottlenecks associated with research programmes that researchers and CGIAR identified,” says Carmen Thönnissen (pictured), Senior Advisor at SDC.

“GCP is also in line with SDC’s internal guidelines on Green Biotechnology, where it is our aim not to support single-donor initiatives but to work in larger programmes that have a clear focus on strengthening the national partner capacities too.”

At the beginning, most project leaders were from developed nations and CGIAR Centres. … now more than half of our projects are led by scientists in developing countries.”

A structured revolution within an evolution: aiming for products and sustainable change
GCP was designed in two phases over its 10-year life. The first was about the research and using genetic plant breeding techniques. The second and current phase focuses more on accessing modern breeding technologies and building capacity in developing countries to do the research for themselves.

Within nine years, GCP has produced useful tools and products from its studies of genetic resources.
These products have contributed to advancing knowledge, and will continue to do so into the future, particularly in plant breeding.

“At the very beginning, most project leaders were from established universities and institutes  in developed nations, and CGIAR Centres. However, over time there has been a major shift and now we are proud that more than half of our projects are led by scientists in developing countries,” says Jean-Marcel. “They’ve moved from the position of implementers to the role of leaders, while the CGIAR Centres and institutes in developed countries have evolved more into mentors and teachers. We hope this empowerment will allow national programmes to grow and establish themselves to be sustainable when the funding dries up.”

Challenges within the Challenge Programme
All this talk about spirit, collaboration and partnerships does make it sound as if GCP has found the winning formula, but Jean-Marcel is quick to counter such notions, and there have been constant course corrections in charting the Programme’s path. “If anything, our strength comes from recognising our weaknesses, acknowledging that we don’t have it all worked out, and embracing change where it is needed.”

A mid-term external review was conducted in 2008 to audit the Programme’s weaknesses, strengths and lessons learnt from both. This review resulted in some governance reforming, bringing about the Consortium Committee and an independent Executive Board.

“It’s a major improvement that we have an independent Board, allowing for focus, and without any conflict of interest. I think they are doing a great job,” says Jean-Marcel. “They are monitoring and evaluating what we are doing, providing plenty of feedback and ideas on how to move forward, and contributing a lot to the success of the Programme.”

The Board’s focus now turns to auditing the Programme and mapping a strategy to sustain its successful partnerships and systems, so they can continue to deliver products and capacity to the developing world.

Bird’s eye view from the Board
With more than 45 years of experience in international development and disaster management and, having worked in development programmes in Africa, Asia, Latin America, the Pacific and the Caribbean, Andrew Bennett (pictured) was a perfect candidate for the Board Chair.

“We are committed to the role that can be played by science in development, and to the Programme,” says Andrew. “We have offered advice and helped the Programme’s Consortium Committee and management refocus the Programme. By all accounts, they seem happy with how things have evolved.”

Advice and helping aren’t normally the words associated with how a Board works but, like so much of the GCP family, this isn’t a classical board.

Andrew explains “Because GCP is hosted by CIMMYT, the Board does not have to deal with any policy issues. That is the responsibility of the Consortium Committee. Our role is more to provide advice and to help with decision-making and implementation, which is great as we’ve been able to focus on the Programme’s science and people.”

That focus now turns to auditing the Programme and mapping a strategy to sustain its successful partnerships and systems, so they can continue to deliver products and capacity to the developing world.

Turning sunset to sunrise
With only two-and-a-half years left to run, Jean-Marcel and his team are working just as passionately on sustaining the partnerships, projects and outputs that GCP has created.

“We knew we weren’t going to be around forever, so we had a plan from early on to hand over the managerial reins to other institutes, including CGIAR,” says Jean-Marcel, with the slight affliction of a parent helping their child move out of home.

“We have begun integrating projects into the CGIAR Research Programmes (CRPs) which we hope will allow them to continue to grow and work effectively towards the goals set.”

At the same time, the Management Team, Committee and Board are all busy auditing the successes and failures of the Programme to quantify the achievements of what has been termed as one of the CGIAR’s more successful Challenge Programmes, and on how to make GCP products freely accessible to other research institutes and programmes.

Relevant links

Links to external websites

 

Jun 262012
 

It’s all about water and weakness  or strength. The Greek legend has it that Achilles was dipped into River Styx by his mother, Thetis, in order to make him invulnerable. His heel wasn’t covered by the water and he later died of the wound from an arrow that struck his heel.

In our times, this analogy can be applied to chickpeas, where this streetwise tough customer in the crop kingdom that thrives on the most rugged terrains is hamstrung if there is no rain at the critical grain-filling period – its sole Achilles’ heel, when it cannot take the searing heat in the drylands it otherwise thrives in.

But before you read on about the latter-day borrowing of this ancient legend, and science’s quest to heal the hit from heat and to cure the crop’s fatal flaw on water, first, an important aside…

Who’s now calling the shots in chickpea research?

Molecular breeding in Phase I was led by ICRISAT, with country partners in a supporting role. In Phase II, activities are being led by country partners, which also assures sustainability and continuity of the work. ICRISAT is now in a facilitating role, providing training and data, while the research work is now in the hands of country partners.” – Pooran Gaur, Principal Scientist: Chickpea Breeding,  ICRISAT.

The facts
Chickpeas are an ancient crop that was first domesticated in central and western Asia. Today, this crop is cultivated in 40 countries and is second only to common beans as the food legume most widely grown by smallholders. The two main types of chickpeas – desi and kabuli – are valuable for both subsistence and cash.

Even for the hardy, times are tough
“Chickpeas are well-known to be drought-tolerant,” says Rajeev K Varshney, Principal Investigator of the project to improve chickpeas work in the Tropical Legumes I Project (TLI). He explains, “The plants are very efficient in using water and possess roots that seek out residual moisture in deeper soil layers.” However, he points out that, with changing climatic conditions, especially in drier areas, terminal drought – when rain does not fall during grain-filling – is the crop’s Achilles’ heel, and principal production constraint.

“Chickpeas are such tough plants that, even for conditions of terminal drought, yields can be increased by improving root characteristics and water-use efficiency,” says Rajeev. The research team has identified several lines with superior traits such as drought tolerance, after screening a set of 300 diverse lines selected based on molecular diversity of large germplasm collections.

VIDEO CLIP: Recipe for chickpea success

Enhancing the genetic makeup to beat the heat
The team went on to develop genomic resources such as molecular markers. With these markers, the team developed a high-density genetic map, and identified a genomic region containing several quantitative trait loci (QTLs), conferring drought tolerance. “QTLs help pinpoint, more specifically, the location of genes that govern particular traits like root length” explains Rajeev.

Longer roots will naturally give the plants a deeper reach into the water table. Root length is the difference between survival and perishing, which is why trees will be left standing on a landscape otherwise laid bare by prolonged drought.

Q for ‘quick’: QTLs speed things along from lab to field, and running with the winners
The discovery of QTLs makes identifying tolerant plants not only easier, but also cheaper and faster. “This means that better-adapted varieties will reach farmers faster, improving food security,” says Rajeev.

Pooran Gaur, GCP’s Product Delivery Coordinator for chickpeas, Principal Scientist for Chickpea Breeding at ICRISAT, and an important collaborator on the TLI project, adds, “We began marker-assisted selection backcrossing (MABC) in Phase I. By 2011, lines were already being evaluated in Ethiopia, India and Kenya. We are now at the stage of singling out the most promising lines.”

Putting chickpeas to the test: Rajeev Varshney (left) and Pooran Gaur (right) inspecting a chickpea field trial.

What was achieved in Phase I, and what outcomes are expected?
Phase I run from mid-2007 to mid-2010, during which time 10 superior lines for improved drought tolerance and insect resistance were identified for Ethiopia, Kenya and India. As well, a total of 1,600 SSR markers and 768 SNPs on GoldenGate assays were developed, along with an expanded DArT array with more than 15,000 features. A high-density reference genetic map and two intraspecific genetic maps were developed.

“We now have materials from marker-assisted backcrossing by using the genomic resources we produced in Phase I. These materials were sent to partners last year [2011]. And because in most cases we have the same people working in TLI as in TLII, this material is being simultaneously evaluated across six to seven locations by all TLI and TLII partners,” says Pooran.

“Preliminary analysis of data is quite encouraging and it seems that we will have drought-tolerant lines soon,” adds Rajeev.

Future work, and who’s now calling the shots in the field
In Phase II, 1,500 SNPs on cost-effective KASPar assays have been developed that have been useful to develop a denser genetic map. In collaboration with University of California–Davis (USA) and the National Institute of Plant Genome Research (India), a physical map has been developed that will help to isolate the genes underlying the QTL region for drought tolerance. A novel molecular breeding approach called marker-assisted recurrent selection (MARS) has been adopted. Over the remaining two years of Phase II, the chickpea work will focus on developing chickpea populations with superior genotypes for drought tolerance through MABC and MARS.

Pooran adds, “Molecular breeding in Phase I was led by ICRISAT, with country partners in a supporting role. In Phase II, activities are being led by country partners, which also assures sustainability and continuity of the work. ICRISAT is now in a facilitating role, providing training and data, while the MABC and MARS aspects are both in the hands of country partners.”

“Another important activity in Phase II is development of multi-parents advanced generation intercross (MAGIC) population that will help generation of genetic populations with enhanced genetic diversity,” says Rajeev.

Partnerships
The chickpea work is led by the International Crops Research Institute for the Semi-Arid Tropics (ICRISAT), working with partners at the Ethiopian Institute of Agricultural Research, Egerton University in Kenya, and the Indian Agricultural Research Institute. Additional collaborators in Phase I included the University of California–Davis (USA), the National Center for Genome Resources (USA) and DArT P/L (Australia).

For more information on the overall work in chickpeas, please contact Rajeev K Varshney, Principal Investigator of the chickpea work.

Video: Featuring Rajeev and partners Fikre Asnake (Ethiopia) and Paul Kimurto (Kenya)

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